PS supplements, Pycnogenol, Robuvit, Centellicum. New clinical and preventive applications

Supplementation with PS supplements (supplements with pharmaceutical standards) must follow some new rules concerning the quality of the products and their pharmaceutical consistency. The new field of ‘supplementary medicine’ - based on PS supplements - is expanding, replacing many alternative or complementary methods associated to poor science, limited results or without evidence. Supplement studies (usually registries) define the field of activity of PS supplements and possible, preventive, preferably non-clinical or pre-clinical applications. They are planned and organized with the full attention and participation of the evaluation subjects. Safety is the first point to define. All PS supplements are by definition recognized as safe (RAS). The best fields of application for PS supplements are preclinical, borderline ‘preventive’ applications or the supplementary management of some risk conditions. Supplements - unless there are specific claims - are not generally used as the main standard treatments of signs/symptoms or severe clinical conditions. Supplementary medicine and PS supplements are the new method & tools to perform a softer, effective and low-risk, shared, com-part medicine. PS supplements are not drugs (all drugs are quoted in the Goodman & Gilman’s: The Pharmacological Basis of Therapeutics; Mc Graw Hill). PS supplements create a bright clinical and business future. INDEX PROSTATIC FIBROSIS; IMPROVEMENT IN TISSUE MORPHOLOGY AND SYMPTOMS OF ENLARGED PROSTATE WITH THE COMBINATION PYCNOGENOL® AND CENTELLICUM® - Ledda A., Dugall M., Hu S., Belcaro G., Peterzan P., Hosoi M., Cotellese R., Cesarone M. R., Scipione C., Scipione V. SUPPLEMENTARY MANAGEMENT IN SUBJECTS WITH PARKINSON’S DISEASE AND MILD COGNITIVE IMPAIRMENT WITH PYCNOGENOL® - Cesarone M. R., Belcaro G., Hu S., Hosoi M., Ledda A., Feragalli B., Zuccarini M., Luzzi R. EXPLORING THE CONCEPT OF VIGOR AND DYS-VIGOR IN MEN OF 50-65 YEARS: EFFECTS OF ROBUVIT® - Hosoi M., Cesarone M. R,. Dugall M., Hu S., Belcaro G., Peterzan P., Cotellese R. CENTRAL CARDIOVASCULAR CALCIFICATIONS VARIATIONS IN 12 MONTHS WITH PYCNOGENOL®-CENTELLICUM® SUPPLEMENTATION - Hu S., Belcaro G., Cesarone M.R., Feragalli B., Cotellese R., Dugall M. PROGRESSION AND OCCURRENCE OF CARDIOVASCULAR EVENTS IN ASYMPTOMATIC PATIENTS WITH ATHEROSCLEROTIC PLAQUES; EFFECTS OF THE COMBINED - SUPPLEMENTATION WITH PYCNOGENOL®+CENTELLICUM® - Cesarone M.R., Dugall M., Hu S., Belcaro G., Peterzan P., Luzzi R., Hosoi M., Cotellese R. PYCNOGENOL®+CENTELLICUM®, POST-STENTS EVALUATION. CONTROL OF NEOINTIMA AND PLAQUE RE-GROWTH AT 12 MONTHS - Cesarone M.R., Dugall M., Hu S., Belcaro G., Peterzan P.,Feragalli B., Luzzi R., Hosoi M., Cotellese R. EPISODIC PRIMARY MIGRAINE HEADACHE: PROPHYLAXIS WITH PYCNOGENOL® PRECENTS ATTACKS AND CONTROLS OXIDATIVE STRESS - Cesarone M.R., Dugall M., Hu S., Belcaro G., Peterzan P., Luzzi R., Hosoi M., Cotellese R. XEROSTOMIA AND PYCNOGENOL® SUPPLEMENTATION A PILOT, CONCEPT STUDY - Belcaro G., Cesarone M.R., Dugall M., Hu S., Peterzan P., Feragalli B., Luzzi R., Hosoi M., Cotellese R. MILD HEART FAILURE: EFFECTS OF ROBUVIT® IN A PILOT REGISTRY - Cesarone M.R., Belcaro G., Dugall M., Hu S., Corsi M., Hosoi M., Luzzi R., Cotellese R., Olivier Ni., Feragalli B., Ledda A. PRIMARY SPONTANEOUS EDEMA OF PROBABLE LYMPHATIC ORIGIN. A CONCEPT, REGISTRY STUDY. EFFECTS OF ROBUVIT® IN DIFFUSE, MINIMAL LYMPHATIC ‘RETENTION’ (DMLR) - Hu S., Belcaro G., Hosoi M., Cesarone M.R., Dugall M., Peterzan P., Cotellese R. HANGOVER AND FATIGUE; EFFECTIVENESS OF ROBUVIT® SUPPLEMENTATION - Hosoi M., Cornelli U., Hu S., Belcaro G., Cesarone M.R., Pellegrini L., Dugall M., Peterzan P., Cotellese R. A SUPPLEMENTARY APPROACH TO VAGINAL DRYNESS IN HEALTHY PERI-MENOPAUSAL WOMEN WITH LADY PRELOX® 4 - Cesarone M.R., Belcaro G., Cornelli U., Dugall M., Hu S., Corsi M., Hosoi M., Luzzi R., Cotellese R., Feragalli B., Ledda A. SUPPLEMENTARY MANAGEMENT WITH PYCNOGENOL® OF PATIENTS IN REMISSION PHASES OF LUPUS VASCULITIS: A PILOT REGISTRY STUDY - Cesarone M.R., Belcaro G., Hu S., Hosoi M., Ledda A., Feragalli B., Zuccarini M., Luzzi R.