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Advanced Therapy for Hepatitis C [McCaughan - Wiley - Blackwell]

ISBN/EAN
9781405187459
Editore
Wiley - Blackwell
Formato
Cartonato
Anno
2011
Pagine
232

Disponibile

101,30 €
According to the WHO, 170 million people, or 3% of the world's population, are infected with Hepatitis C and at risk of developing liver cirrhosis and/or liver cancer. 3-4 million people each year are newly diagnosed carriers of the virus. Advanced Therapy for Hepatitis C Infection provides you with expert guidance from the world’s leading hepatologists on the very latest treatment options for patients with the HCV virus. Focusing mainly on the efficacy and clinical use of antiviral therapies, key topics include: Treatment of recurrent hepatitis C following liver transplantation Antivirals in Cirrhosis and Portal Hypertension HIV and Hepatitis C co-infection Cytopenias: how they limit therapy and potential correction The problem of insulin resistance and its effect on therapy Antivirals in Acute Hepatitis C In addition, it fully covers the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. Finally, a chapter on New Horizons: Interleukin 28 and direct-acting antiviral therapy for HCV, offers you a glimpse into the future possibilities for HCV therapy. Edited by a team of outstanding international reputation, Advanced Therapy for Hepatitis C Infection is an essential tool for all hepatologists and gastroenterologists involved in the management of patients with Hepatitis C.

Maggiori Informazioni

Autore McCaughan Geoffrey W.; McHutchison John; Pawlotsky Jean-Michel
Editore Wiley - Blackwell
Anno 2011
Tipologia Libro
Lingua Inglese
Indice Section I Foundations for Understanding Antiviral Therapies in HCV 1 HCV Replication 3 Michael R. Beard 2 Hepatitis C Virus Genotypes 12 Scott A. Read and Mark W. Douglas 3 Immune Responses to HCV: Implications for Therapy 17 David G. Bowen 4 Mechanisms of Action of Antiviral Drugs: The Interferons 25 Edmund Tse and Michael R. Beard 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs 36 Fred Poordad and Grace M. Chee 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors 43 Lotte Coelmont Leen Delang Mathy Froeyen Piet Herdewijn and Johan Neyts 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors 53 Laurent Chatel-Chaix Martin Baril and Daniel Lamarre 8 Measuring Antiviral Responses 60 Jean-Michel Pawlotsky and Stephane Chevaliez Section II Efficacy and Clinical Use of Antiviral Therapies 9 Genotype 1: Standard Treatment 67 Rebekah G. Gross and Ira M. Jacobson 10 Individually Tailored Treatment Strategies in Treatment-na¨ive Chronic Hepatitis C Genotype 1 Patients 74 Johannes Wiegand and Thomas Berg 11 Genotype 1 Relapsers and Non-responders 84 Salvatore Petta and Antonio Craxì 12 Standard Therapy for Genotypes 2/3 90 Kenneth Yan and Amany Zekry 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3 97 Alessandra Mangia Leonardo Mottola and Angelo Andriulli 14 Genotypes 2 and 3 Relapse and Non-response 104 Stella Mart´inez Jose Maria Sanchez-Tapias and Xavier Forns 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges 113 Sanaa M. Kamal 16 Antivirals in Acute Hepatitis C 127 Heiner Wedemeyer 17 Antivirals in Cirrhosis and Portal Hypertension 132 Diarmuid S. Manning and Nezam H. Afdhal 18 Treatment of Recurrent Hepatitis C Following Liver Transplantation 140 Ed Gane 19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations 150 Benjamin Terrier and Patrice Cacoub 20 Cytopenias: How they Limit Therapy and Potential Correction 160 Mitchell L. Shiffman 21 The Problem of Insulin Resistance and its Effect on Therapy 169 Venessa Pattullo and Jacob George 22 HIV and Hepatitis C Co-infection 177 Gail V. Matthews and Gregory J. Dore 23 HCV and Racial Differences 185 Andrew J. Muir 24 HCV and the Pediatric Population 190 Kathleen B. Schwarz 25 New Horizons: IL28 Direct-acting Antiviral Therapy for HCV 196 Alexander J. Thompson John G. McHutchison and Geoffrey W. McCaughan Index 215
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